I took an AG/AB combo test for HIV a week after having symptoms. Would p24 antigen or antibodies show at this time? When should I test again?

 While I cannot definitively diagnose you or offer medical advice, I can share some information about AG/AB combo tests and HIV detection windows to help you understand the potential results and next steps.

AG/AB Combo Test:

This test is a fourth-generation HIV test, capable of detecting both p24 antigen (indicating early acute infection) and HIV antibodies (developed later in the infection course).

Detection Windows:

• p24 antigen: can be detected 14-45 days after exposure.
• HIV antibodies: detectable 18-90 days after exposure.

Your Situation:

Since it's only been a week since you experienced symptoms, it's too early for antibodies to be reliably detected in most cases. However, the p24 antigen might be present if you have a very recent infection.

Test Result Interpretation:

• Negative: This most likely indicates no HIV infection, but due to the early stage, a follow-up test is recommended.
• Positive: Further testing is needed to confirm the result and distinguish between p24 antigen and antibodies.

When to Test Again:

Due to the limitations of early detection, here's what's recommended:

1. Repeat the AG/AB combo test in 3-4 weeks: This allows enough time for antibody development.

2. Consider an earlier repeat test with a different method:

   • Nucleic Acid Test (NAT): Detects HIV RNA (genetic material) as early as 10-33 days after exposure. This is the most accurate early detection test but not always readily available.
   • Rapid HIV test: Some rapid tests detect p24 antigen, offering earlier results than antibody-based rapid tests. However, they might not be as accurate as lab tests.

Seek Professional Guidance:

Consulting a healthcare professional is crucial. They can discuss your risk factors, symptoms, and test results in detail to provide personalized advice. They can also recommend the most appropriate testing strategy and connect you with further support if needed.

Remember, early diagnosis and treatment of HIV are crucial for optimal health outcomes. Please don't hesitate to seek professional guidance for comprehensive management and peace of mind.